The inverse correlation observed between Alzheimerâ??s disease (AD) and cancer has\nprompted us to look for cholinesterase-inhibiting activity in phenothiazine derivatives that possess\nanticancer properties. With the use of in silico and in vitro screening methods, our study found a\nnew biological activity in anticancer polycyclic, tricyclic, and tetracyclic compounds. The virtual\nscreening of a library of 120 ligands, which are the derivatives of azaphenothiazine, led to\nthe identification of 25 compounds that can act as potential inhibitors of acetylcholinesterase\n(AChE) and butyrylcholinesterase (BuChE). Biological assays revealed the presence of selective\ninhibitors of eeAChE (electric eel AChE) or eqBuChE (equine serum BuChE) and nonselective inhibitors\nof both enzymes among the tested compounds...........................................................................................
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